Tracking iron in multiple sclerosis: a combined imaging and histopathological study at 7 Tesla.

@article{Bagnato2011TrackingII,
  title={Tracking iron in multiple sclerosis: a combined imaging and histopathological study at 7 Tesla.},
  author={Francesca R Bagnato and Simon Hametner and Bing Yao and Peter van Gelderen and Hellmut Merkle and Fredric K. Cantor and Hans Lassmann and Jeff H. Duyn},
  journal={Brain : a journal of neurology},
  year={2011},
  volume={134 Pt 12},
  pages={3602-15}
}
Previous authors have shown that the transverse relaxivity R(2)* and frequency shifts that characterize gradient echo signal decay in magnetic resonance imaging are closely associated with the distribution of iron and myelin in the brain's white matter. In multiple sclerosis, iron accumulation in brain tissue may reflect a multiplicity of pathological processes. Hence, iron may have the unique potential to serve as an in vivo magnetic resonance imaging tracer of disease pathology. To… CONTINUE READING