Tracking human migrations by the analysis of the distribution of HLA alleles, lineages and haplotypes in closed and open populations.

@article{Via2012TrackingHM,
  title={Tracking human migrations by the analysis of the distribution of HLA alleles, lineages and haplotypes in closed and open populations.},
  author={Marcelo A Fernandez Vi{\~n}a and Jill A. Hollenbach and Kirsten E. Lyke and Marcelo B. Sztein and Martin Maiers and William J. Klitz and Pedro Cano and Steven J. Mack and Richard M. Single and Chaim Brautbar and Shosahna Israel and Eduardo Raimondi and Evelyne Khoriaty and Adlette Inati and Marco Andreani and Manuela Testi and Maria Elisa Hue Moraes and G. Thomson and Peter Stastny and Kai Ming Cao},
  journal={Philosophical transactions of the Royal Society of London. Series B, Biological sciences},
  year={2012},
  volume={367 1590},
  pages={820-9}
}
The human leucocyte antigen (HLA) system shows extensive variation in the number and function of loci and the number of alleles present at any one locus. Allele distribution has been analysed in many populations through the course of several decades, and the implementation of molecular typing has significantly increased the level of diversity revealing that many serotypes have multiple functional variants. While the degree of diversity in many populations is equivalent and may result from… CONTINUE READING