Tracking down contact activation - from coagulation in vitro to inflammation in vivo.

@article{Maat2014TrackingDC,
  title={Tracking down contact activation - from coagulation in vitro to inflammation in vivo.},
  author={Steven de Maat and Claudia Tersteeg and Eszter Herczenik and Coen Maas},
  journal={International journal of laboratory hematology},
  year={2014},
  volume={36 3},
  pages={374-81}
}
The contact system is a volatile and versatile enzyme system in blood plasma that responds to the presence of nonphysiological surface materials by spontaneous generation of enzymatic activity. In subsequent steps, it can trigger blood coagulation and is responsible for the generation of the proinflammatory peptide bradykinin. The physiological role of the contact system is presently unknown, but it is commonly used to trigger coagulation in a diagnostic setting. In this three-part review, we… CONTINUE READING

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