Tracking FACT and the RNA polymerase II elongation complex through chromatin in vivo.

@article{Saunders2003TrackingFA,
  title={Tracking FACT and the RNA polymerase II elongation complex through chromatin in vivo.},
  author={Abbie Saunders and Janis Werner and Erik D. Andrulis and Takahiro Nakayama and Susumu Hirose and Danny F Reinberg and John T Lis},
  journal={Science},
  year={2003},
  volume={301 5636},
  pages={1094-6}
}
RNA polymerase II (Pol II) transcription through nucleosomes is facilitated in vitro by the protein complex FACT (Facilitates Chromatin Transcription). Here we show that FACT is associated with actively transcribed Pol II genes on Drosophila polytene chromosomes. FACT displays kinetics of recruitment and of chromosome tracking in vivo similar to Pol II and elongation factors Spt5 and Spt6. Interestingly, FACT does not colocalize with Pol III-transcribed genes, which are known to undergo… CONTINUE READING
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