Tracking Effects of SIL1 Increase: Taking a Closer Look Beyond the Consequences of Elevated Expression Level

@article{Labisch2017TrackingEO,
  title={Tracking Effects of SIL1 Increase: Taking a Closer Look Beyond the Consequences of Elevated Expression Level},
  author={Thomas Labisch and Stephan Buchkremer and Vietxuan Phan and Laxmikanth Kollipara and Christian Gatz and Chris Lentz and Kay Wilhelm Nolte and J{\"o}rg Vervoorts and Jos{\'e} Andr{\'e}s Gonz{\'a}lez Coraspe and Albert Sickmann and Stephanie G. Carr and Ren{\'e} Peiman Zahedi and Joachim Weis and Andreas Roos},
  journal={Molecular Neurobiology},
  year={2017},
  volume={55},
  pages={2524-2546}
}
SIL1 acts as a co-chaperone for the major ER-resident chaperone BiP and thus plays a role in many BiP-dependent cellular functions such as protein-folding control and unfolded protein response. Whereas the increase of BiP upon cellular stress conditions is a well-known phenomenon, elevation of SIL1 under stress conditions was thus far solely studied in yeast, and different studies indicated an adverse effect of SIL1 increase. This is seemingly in contrast with the beneficial effect of SIL1… CONTINUE READING
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