Tracing the evolutionary history of Drosophila regulatory regions with models that identify transcription factor binding sites.

@article{Dermitzakis2003TracingTE,
  title={Tracing the evolutionary history of Drosophila regulatory regions with models that identify transcription factor binding sites.},
  author={Emmanouil T. Dermitzakis and Casey M. Bergman and Andrew G. Clark},
  journal={Molecular biology and evolution},
  year={2003},
  volume={20 5},
  pages={703-14}
}
Much of evolutionary change is mediated at the level of gene expression, yet our understanding of regulatory evolution remains unsatisfying. In light of recent data indicating that transcription factor binding sites undergo substantial turnover between species, we attempt to quantify the process of binding site turnover in regulatory regions of well-studied… CONTINUE READING