Tracing lipogenesis in humans using deuterated water.

  title={Tracing lipogenesis in humans using deuterated water.},
  author={Peter Jh Jones},
  journal={Canadian journal of physiology and pharmacology},
  volume={74 6},
  • Peter Jh Jones
  • Published 1996 in Canadian journal of physiology and pharmacology
Determination of quantitative de novo fat synthesis rates is important in our understanding of the role of nutritional factors in macronutient utilization and obesity development. To address these questions, we developed and applied a method for measuring lipogenesis using the uptake of deuterium from heavy water into triglyceride fatty acids (TGFA) in humans. Our model examined the plateau of deuterium enrichment in plasma very light density lipoprotein (VLDL) TGFA relative to the maximum as… CONTINUE READING


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