Tracing hematopoietic precursor migration to successive hematopoietic organs during zebrafish development.

  title={Tracing hematopoietic precursor migration to successive hematopoietic organs during zebrafish development.},
  author={Emi Murayama and Karima Kissa and Agust{\'i}n Zapata and Elodie Mordelet and Val{\'e}rie Briolat and Hui-feng Lin and Robert I. Handin and Philippe Herbomel},
  volume={25 6},
Although the ontogeny of hematopoietic stem cells (HSCs) in vertebrates has been studied intensely, a lineage relationship between the HSCs found in the developmentally successive hematopoietic organs remains to be shown. By using an in situ photoactivatable cell tracer in the transparent zebrafish embryo, we demonstrated that definitive blood precursors appeared between the dorsal aorta and axial vein, validating the homology of this tissue with the AGM (aorta-gonad-mesonephros) of amniotes… CONTINUE READING
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