Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells.

@article{Lewis2014TracingCN,
  title={Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells.},
  author={Caroline A Lewis and Seth J. Parker and Brian P. Fiske and Douglas McCloskey and Dan Yi Gui and Courtney R. Green and Natalie I Vokes and Adam M. Feist and Matthew G Vander Heiden and Christian M. Metallo},
  journal={Molecular cell},
  year={2014},
  volume={55 2},
  pages={253-63}
}
Eukaryotic cells compartmentalize biochemical processes in different organelles, often relying on metabolic cycles to shuttle reducing equivalents across intracellular membranes. NADPH serves as the electron carrier for the maintenance of redox homeostasis and reductive biosynthesis, with separate cytosolic and mitochondrial pools providing reducing power in each respective location. This cellular organization is critical for numerous functions but complicates analysis of metabolic pathways… CONTINUE READING