Tracing Woody Guthrie and Huntington's disease.

@article{Arevalo2001TracingWG,
  title={Tracing Woody Guthrie and Huntington's disease.},
  author={J. Arevalo and J. Wojcieszek and P. Conneally},
  journal={Seminars in neurology},
  year={2001},
  volume={21 2},
  pages={
          209-23
        }
}
Tracing the outlines of Woody Guthrie's life can be maddening. His outpouring of songs, words, and images attests to the rare creative spirit which possessed him like a devil, or angel, more often both. He was a figure which many of us hold dear as an emblematic American symbol of outspoken and independence-minded social consciousness. Drawn from Guthrie's collection of published and unpublished material in the Woody Guthrie Archives, including song lyrics, poems, prose, artwork--in short… Expand

Paper Mentions

The Huntington Disease of Woody Guthrie: Another Man Done Gone
  • J. Ringman
  • Psychology, Medicine
  • Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology
  • 2007
TLDR
Guthrie's art is explored in relation to the development of the overt behavioral changes and chorea that characterized his illness to hypothesize that subclinical HD may have been an important driving force behind Woody Guthrie's creativity. Expand
Degenerative diseases Mild cognitive impairment: diagnosing Alzheimer's in the pre-dementia stage Related review: Mild cognitive impairment
. Bookheimer SY, Strojwas MH, Cohen MS, Saunders AM, PericakVance MA, Mazziotta JC, Small GW. Patterns of brain activation in people at risk for Alzheimer's disease. N Engl J Med 2000; 343:450±456.Expand
Hearing and music in dementia.
TLDR
The aim of this chapter is to review the current state of knowledge concerning hearing and music perception in persons who have a dementia as a result of a neurodegenerative disease, with a particular focus on the processing of music and other non-verbal sounds. Expand
The Woody Guthrie Centennial Bibliography
This bibliography updates two extensive works designed to include comprehensively all significant works by and about Woody Guthrie. Richard A. Reuss published A Woody Guthrie Bibliography, 1912–1967Expand
Counseling Psychology in the Era of Genetic Testing
The field of genetics and the process of testing for genetic disorders have advanced considerably over the past half century, ushering in significant improvements in certain areas of medicalExpand
Huntington disease: a nursing perspective.
  • H. Skirton
  • Medicine
  • Medsurg nursing : official journal of the Academy of Medical-Surgical Nurses
  • 2005
TLDR
Nurses play a vital role as health care providers and advocates for the patient with Huntington disease, and have a significant impact on the social life of the family. Expand

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TLDR
It is demonstrated that lesions due to quinolinic acid closely resemble those of HD as they result in marked depletions of both GABA and substance P, with selective sparing of somatostatin/neuropeptide Y neurones. Expand
Behavioral pathology induced by repeated systemic injections of 3-nitropropionic acid mimics the motoric symptoms of Huntington's disease
TLDR
It is reported that systemic administration of 3-nitropropionic acid, an inhibitor of the mitochondrial citric acid cycle, results in a progressive locomotor deterioration resembling that of HD and that this animal model can be used to test experimental treatments for HD across different stages of the disease. Expand
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TLDR
Assays at the biochemical, cellular, and whole organism levels are starting to yield potential disease modifying genes and candidate drugs and can be prioritized by testing in a panel of genetic and phenotypic HD mouse models to yield analytical tools for dissecting the early and late stages of the disease process. Expand
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TLDR
There was a trend toward lower lactate/creatine ratios during riluzole treatment in the basal ganglia spectra but not in occipital cortex spectra, and additional clinical studies of rILuzole for both symptomatic and neuroprotective benefit in Huntington's disease are warranted. Expand
Mitochondrial defect in Huntington's disease caudate nucleus
TLDR
The mitochondrial defect identified in HD caudate parallels that induced by HD neurotoxin models and further supports the role of abnormal energy metabolism in HD. Expand
Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease
TLDR
Evidence of caspase-1 activation in the brains of mice and humans with Huntington's disease is demonstrated and it is demonstrated that intracerebroventricular administration of a casp enzyme inhibitor delays disease progression and mortality in the mouse model of Huntington’s disease. Expand
Evidence for impairment of energy metabolism in vivo in Huntington's disease using localized 1H NMR spectroscopy.
TLDR
Lactate concentrations were increased in the occipital cortex of symptomatic HD patients when compared with normal controls, and the lactate level correlated with duration of illness, consistent with a possible defect in energy metabolism in HD. Expand
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TLDR
Evidence for a generalized energy defect in Huntington's disease is provided, and a possible therapy is suggested to treat patients with coenzyme Q10. Expand
Differential clinical and motor control function in a pair of monozygotic twins with Huntington's disease
We report a pair of monozygotic Huntington's disease (HD) twins who, although sharing identical CAG repeat lengths, not only present with marked differences in clinical symptoms but also behavioralExpand
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
TLDR
The Huntington's disease mutation involves an unstable DNA segment, similar to those described in fragile X syndrome, spino-bulbar muscular atrophy, and myotonic dystrophy, acting in the context of a novel 4p16.3 gene to produce a dominant phenotype. Expand
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