Tracheoesophageal fistula formation in patients with lung cancer treated with chemoradiation and bevacizumab.

@article{Spigel2010TracheoesophagealFF,
  title={Tracheoesophageal fistula formation in patients with lung cancer treated with chemoradiation and bevacizumab.},
  author={David Robert Spigel and John D Hainsworth and Denise A Yardley and Eric A Raefsky and Jeffrey F Patton and Nancy Walker Peacock and Cindy P Farley and Howard A. Burris and Frank Anthony Greco},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2010},
  volume={28 1},
  pages={43-8}
}
PURPOSE Tracheoesophageal fistulae are rare complications of thoracic cancers and their treatments. Novel antiangiogenic agents in cancer treatment such as bevacizumab potentially impact wound healing and may contribute to tracheoesophageal fistula development. PATIENTS AND METHODS We conducted two independent phase II clinical trials in small-cell lung cancer and non-small-cell lung cancer using bevacizumab in combination with chemotherapy and radiation. Both trials were intended to assess… CONTINUE READING