Tracheal ligation increases cell proliferation but decreases surfactant protein in fetal murine lungs in vitro.

@article{Bullard1997TrachealLI,
  title={Tracheal ligation increases cell proliferation but decreases surfactant protein in fetal murine lungs in vitro.},
  author={Kelli M. Bullard and Jesper Sonne and Samuel B Hawgood and Michael R. Harrison and N. Scott Adzick},
  journal={Journal of pediatric surgery},
  year={1997},
  volume={32 2},
  pages={207-11; discussion 211-3}
}
Tracheal occlusion affects both fetal lung growth and maturation. The authors used a murine in vitro whole organ culture model to investigate these effects. The authors hypothesized that tracheal ligation would increase lung growth by increasing cell proliferation and would change surfactant protein synthesis in this system. Lungs were removed from day 14… CONTINUE READING