Tracheal development and the von Hippel–Lindau tumor suppressor homolog in Drosophila

@article{Adryan2000TrachealDA,
  title={Tracheal development and the von Hippel–Lindau tumor suppressor homolog in Drosophila},
  author={Boris Adryan and Hans-Jochen H. Decker and Takis S. Papas and Tien Hsu},
  journal={Oncogene},
  year={2000},
  volume={19},
  pages={2803-2811}
}
von Hippel–Lindau disease is a hereditary cancer syndrome. Mutations in the VHL tumor suppressor gene predispose individuals to highly vascularized tumors. However, VHL-deficient mice die in utero due to a lack of vascularization in the placenta. To resolve the contradiction, we cloned the Drosophila VHL homologue (d-VHL) and studied its function. It showed an overall 50% similarity to the human counterpart and 76% similarity in the crucial functional domain: the elongin C binding site. The… CONTINUE READING
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