Traces of bacterial lipopolysaccharide suppress IFN-gamma-induced nitric oxide synthase gene expression in primary mouse macrophages.

@article{Bogdan1993TracesOB,
  title={Traces of bacterial lipopolysaccharide suppress IFN-gamma-induced nitric oxide synthase gene expression in primary mouse macrophages.},
  author={Christian Bogdan and Yoram Vodovotz and John Paik and Qiao-wen Xie and Carl Nathan},
  journal={Journal of immunology},
  year={1993},
  volume={151 1},
  pages={
          301-9
        }
}
A nitric oxide synthase (iNOS) inducible by cytokines and microbial products contributes to the cytotoxic and antimicrobial activity of mouse macrophages. Bacterial LPS interacts synergistically with IFN-gamma to induce iNOS when both stimuli are added together. In contrast, we show here that pre-exposure of peritoneal macrophages to low concentrations of LPS suppresses the induction of iNOS when IFN-gamma is added subsequently. Suppression required pretreatment with LPS for at least 8 h and… CONTINUE READING

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