Tracer development and hybrid imaging

@article{Yang2005TracerDA,
  title={Tracer development and hybrid imaging},
  author={David J. Yang and E. Edmund Kim},
  journal={European Journal of Nuclear Medicine and Molecular Imaging},
  year={2005},
  volume={32},
  pages={1001-1002}
}
  • David J. Yang, E. Kim
  • Published 6 August 2005
  • Medicine
  • European Journal of Nuclear Medicine and Molecular Imaging
The development of radiolabeled biochemical compounds and imaging devices to detect radioactivity by external imaging has expanded the use of nuclear medicine studies in drug development. Drug discovery and development are accelerating due to rapid synthesis of potential drugs and development of high-throughput in vitro tests. Since imaging can play a major role in drug development because of its ability to quantitate drug properties in vivo, it is beginning to be used in all phases of drug… Expand
The diversity of (68)Ga-based imaging agents.
  • I. Velikyan
  • Medicine
  • Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer
  • 2013
TLDR
This chapter presents some examples of tracers for targeted, pretargeted, and nontargeted imaging with emphasis on the potential of (68)Ga to facilitate clinically practical PET development and to promote the PET technique worldwide for earlier and better diagnostics, and personalized medicine with the ultimate objective of improved therapeutic outcome. Expand
Advances in Radiotracer Development for Molecular Imaging
Molecular imaging is currently defined by the society of nuclear medicine as the visualization, characterization and measurement of biological processes at the molecular and cellular levels in humansExpand
Review: Deoxyglucose compounds labeled with isotopes different from 18-fuoride: is there a future in clinical practice?
TLDR
In the area of molecular imaging of nuclear medicine, derivatives of radionuclide-labeled deoxyglucose will become an important tool for the diagnosis and carcinoma treatment in the clinic. Expand
Molecular imaging of gefitinib activity in an epidermal growth factor receptor (EGFR)-bearing xenograft model
TLDR
The results indicate that 111In-EC-P-Tyr can detect tumor phospho-tyrosine kinase activity in animal models and merits investigation in the clinic to determine if it can predict patient responses to kinase inhibitors based on phosphokinase imaging. Expand
Chelation-Tamoxifen Conjugates for Imaging of Estrogen Receptors.
  • S. Yeh, Wei-Chung Chang, +6 authors David J Yang
  • Medicine
  • Cancer biotherapy & radiopharmaceuticals
  • 2021
TLDR
99mTc-SC-05-N-1 showed better differential diagnosis of ovarian tumors than 18F-FDG, indicating great promising in chelator-tamoxifen conjugate for ER pathway-directed systems imaging. Expand

References

SHOWING 1-10 OF 11 REFERENCES
Tumor Specific Imaging Using Tc-99m and Ga-68 Labeled Radiopharmaceuticals
TLDR
Molecular targets labeled with Tc-99m and Ga-68 can be utilized for prediction of therapeutic response, monitoring tumor response to treatment and differential diagnosis, and their potential to redirect optimal cancer diagnosis and therapeutics were demonstrated. Expand
Imaging with 99 mTc ECDG Targeted at the Multifunctional Glucose Transport System : Feasibility Study with Rodents 1
1 From the Divisions of Diagnostic Imaging (D.J.Y., C.G.K., A.A., D.F.Y., C.S.O., J.L.B., J.J.W., E.E.K., D.A.P.) and Radiation Oncology (N.R.S.), University of Texas M.D. Anderson Cancer Center,Expand
Assessment of therapeutic tumor response using 99mtc-ethylenedicysteine-glucosamine.
TLDR
99mTc-EC-DG is involved in cell nuclei activity and could assess the therapeutic tumor response and the efficacy of paclitaxel and cisplatin treatment in rodent models could be assessed using tumor/muscle ratios. Expand
Occult lung infarction may induce false interpretation of 18F-FDG PET in primary staging of pulmonary malignancies
TLDR
In patients with pulmonary malignancies, synchronous lung infarction may induce pathological FDG accumulation that can mimic active tumour manifestations, which may allow avoidance of false positive FDG PET interpretation. Expand
[(186/188)Re] rhenium-ethylene dicysteine (Re-Ec): preparation and evaluation for possible use in endovascular brachytherapy.
TLDR
The preparation and pharmacological behavior of [(188/186)Re]Re-EC confirms its similarity to (188)Re-MAG(3) and its superiority over ( 188)ReO(4)(-) for use in endovascular brachytherapy. Expand
Vascular endothelial growth factor, hepatocyte growth factor/scatter factor, basic fibroblast growth factor, and placenta growth factor in human meningiomas and their relation to angiogenesis and malignancy.
TLDR
Meningiomas do not show an angiogenic switch involving VEGF and/or hepatocyte growth factor/scatter factor, as has previously been found in gliomas, and the biological activity of V EGF and basic fibroblast growth factor in meningiomas suggests that both are potential targets for antiangiogenic therapy. Expand
Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. Role of hexosamine biosynthesis in the induction of insulin resistance.
TLDR
It is indicated that a unique metabolic pathway exists in adipocytes that mediates desensitization of the insulin-responsive GTS, and that an early step in this pathway involves the conversion of fructose 6-phosphate to glucosamine 6- phosphate by the first and rate-limiting enzyme of the hexosamine pathway, glutamine:fructose-6-ph phosphate amidotransferase. Expand
Intense F-18 FDG accumulation in stomach in a patient with Hodgkin lymphoma: Helicobacter pylori infection as a pitfall in oncologic diagnosis with F-18 FDG PET imaging.
TLDR
Helicobacter pylori is a Gram-negative, spiral rod that has been proved to be responsible for chronic antral gastritis and is accepted as the etiologic factor of gastritis. Expand
Dynamic O-Glycosylation of Nuclear and Cytosolic Proteins
TLDR
Estimation of the recently cloned β-N-acetylglucosaminidase supports the identification of this protein as an O-GlcNAcase and identifies important interactions and modifications that may regulate the enzyme and O- GlcNAc cycling. Expand
Activation of Sp1-mediated Vascular Permeability Factor/Vascular Endothelial Growth Factor Transcription Requires Specific Interaction with Protein Kinase C ζ*
TLDR
A novel pathway whereby Sp1 promotes the transcription of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF), a potent angiogenic factor, by interacting directly and specifically with protein kinase C ζ (PKC ζ) isoform in renal cell carcinoma is described. Expand
...
1
2
...