Tracer-derived total and folate-dependent homocysteine remethylation and synthesis rates in humans indicate that serine is the main one-carbon donor.

@article{Davis2004TracerderivedTA,
  title={Tracer-derived total and folate-dependent homocysteine remethylation and synthesis rates in humans indicate that serine is the main one-carbon donor.},
  author={Steven R. Davis and Peter W. Stacpoole and Jerry Williamson and Lilia S Kick and Eoin P. Quinlivan and Bonnie S Coats and Barry Shane and Lynn B. Bailey and J. Gregory},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2004},
  volume={286 2},
  pages={E272-9}
}
Hyperhomocysteinemia in humans is associated with genetic variants of several enzymes of folate and one-carbon metabolism and deficiencies of folate and vitamins B12 and B6. In each case, hyperhomocysteinemia might be caused by diminished folate-dependent homocysteine remethylation, but this has not been confirmed in vivo. Because published stable isotopic tracer approaches cannot distinguish folate-dependent from folate-independent remethylation, we developed a dual-tracer procedure in which a… CONTINUE READING

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