Trace amine metabolism in Parkinson's disease: Low circulating levels of octopamine in early disease stages

@article{Dandrea2010TraceAM,
  title={Trace amine metabolism in Parkinson's disease: Low circulating levels of octopamine in early disease stages},
  author={G. D'andrea and G. Nordera and G. Pizzolato and A. Bolner and A. Leon},
  journal={Neuroscience Letters},
  year={2010},
  volume={469},
  pages={348-351}
}
Recent evidence suggests that trace amines such as tyramine and octopamine, alternative products of tyrosine metabolism (an aminoacid parent of dopamine and noradrenaline), play a role in the homeostasis of the extrapyramidal system. However, the relevance of these trace amines in the pathogenesis of Parkinson's disease is still largely unknown. Here, we assessed the plasma levels of octopamine and noradrenaline in three sub-groups of PD patients, namely de novo, non-fluctuating and fluctuating… Expand
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