Trace amine-associated receptor 1 activation silences GSK3β signaling of TAAR1 and D2R heteromers

@article{Harmeier2015TraceAR,
  title={Trace amine-associated receptor 1 activation silences GSK3$\beta$ signaling of TAAR1 and D2R heteromers},
  author={Anja Harmeier and Stefanie Obermueller and Claas Aiko Meyer and Florent G. Revel and Dani{\`e}le Buchy and Sylvie Chaboz and Gregor Dernick and Joseph G. Wettstein and Antonio Iglesias and Antonius Rolink and Bernhard Bettler and Marius C. Hoener},
  journal={European Neuropsychopharmacology},
  year={2015},
  volume={25},
  pages={2049-2061}
}
Trace amine-associated receptor 1 (TAAR1) activation by selective endogenous agonists modulates dopaminergic neurotransmission. This results in antipsychotic-like behavior in vivo which might be initiated by an interaction of TAAR1 and dopamine D2L receptor (D2R). Here we analyzed the functional link between TAAR1 and D2R using highly potent and selective TAAR1 agonists, and newly generated tools such as TAAR1 knock-out and TAAR1 overexpressing rats as well as specific anti-rat TAAR1 antibodies… 
Biochemical and Functional Characterization of the Trace Amine-Associated Receptor 1 (TAAR1) Agonist RO5263397
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TLDR
Evidence from electrophysiological and neurochemical studies evaluating the effects of genetic and pharmacological interventions onTAAR1 revealed that TAAR1 modulates transmission of monoamines, especially dopamine, and TAar1 agonists dampened drugs of abuse-induced dopamine accumulation.
Trace Amines and Their Receptors in the Control of Cellular Homeostasis
TLDR
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