Trace amine-associated receptor 1 activation silences GSK3β signaling of TAAR1 and D2R heteromers

  title={Trace amine-associated receptor 1 activation silences GSK3β signaling of TAAR1 and D2R heteromers},
  author={A. Harmeier and Stefan Oberm{\"u}ller and C. A. Meyer and F. G. Revel and M. Hoener},
  journal={European Neuropsychopharmacology},
  • A. Harmeier, Stefan Obermüller, +2 authors M. Hoener
  • Published 2015
  • Biology, Medicine
  • European Neuropsychopharmacology
  • Trace amine-associated receptor 1 (TAAR1) activation by selective endogenous agonists modulates dopaminergic neurotransmission. This results in antipsychotic-like behavior in vivo which might be initiated by an interaction of TAAR1 and dopamine D2L receptor (D2R). Here we analyzed the functional link between TAAR1 and D2R using highly potent and selective TAAR1 agonists, and newly generated tools such as TAAR1 knock-out and TAAR1 overexpressing rats as well as specific anti-rat TAAR1 antibodies… CONTINUE READING
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