Trace Amines and Their Receptors

@article{Gainetdinov2018TraceAA,
  title={Trace Amines and Their Receptors},
  author={R. Gainetdinov and M. Hoener and M. D. Berry},
  journal={Pharmacological Reviews},
  year={2018},
  volume={70},
  pages={549 - 620}
}
Trace amines are endogenous compounds classically regarded as comprising β-phenylethyalmine, p-tyramine, tryptamine, p-octopamine, and some of their metabolites. They are also abundant in common foodstuffs and can be produced and degraded by the constitutive microbiota. The ability to use trace amines has arisen at least twice during evolution, with distinct receptor families present in invertebrates and vertebrates. The term “trace amine” was coined to reflect the low tissue levels in mammals… Expand
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In this Special Issue, leaders in trace amine and TAAR research offer both reviews and original research papers that cover a wide range of topics from involvement of TAAR signaling in metabolic regulation and neurophysiology to implications of this signaling in neuropsychiatric diseases including substance abuse and schizophrenia. Expand
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  • Cell and tissue research
  • 2020
TLDR
The small size of this receptor family combined with the ethological relevance of their ligands makes the TAARs an attractive model system for probing Olfactory perception and whether they represent a unique subsystem within the main olfactory system is discussed. Expand
Increased dopamine transmission and adult neurogenesis in trace amine-associated receptor 5 (TAAR5) knockout mice
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Observations indicate that TAAR5 involved not only in regulation of emotional status but also adult neurogenesis and dopamine transmission, which may provide new treatment opportunity for neurodegenerative disorders such as Parkinson's disease. Expand
Accelerated pseudogenization of trace amine‐associated receptor genes in primates
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Trace Amine-Associated Receptor 1 Contributes to Diverse Functional Actions of O-Phenyl-Iodotyramine in Mice but Not to the Effects of Monoamine-Based Antidepressants
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Trace Amine-Associated Receptor 1 (TAAR1) is a potential target for the treatment of depression and other CNS disorders. However, the precise functional roles of TAAR1 to the actions of clinicallyExpand
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