Trace Amine-Associated Receptor 1 Partial Agonism Reveals Novel Paradigm for Neuropsychiatric Therapeutics

@article{Revel2012TraceAR,
  title={Trace Amine-Associated Receptor 1 Partial Agonism Reveals Novel Paradigm for Neuropsychiatric Therapeutics},
  author={Florent G. Revel and J. Moreau and Raul R Gainetdinov and Antonio Ferragud and Marius C. Hoener},
  journal={Biological Psychiatry},
  year={2012},
  volume={72},
  pages={934-942}
}
BACKGROUND Trace amines, compounds structurally related to classical biogenic amines, represent endogenous ligands of the trace amine-associated receptor 1 (TAAR1). Because trace amines also influence the activity of other targets, selective ligands are needed for the elucidation of TAAR1 function. Here we report on the identification and characterization of the first selective and potent TAAR1 partial agonist. METHODS The TAAR1 partial agonist RO5203648 was evaluated for its binding affinity… CONTINUE READING
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