Trace Amine-Associated Receptor 1 Modulates Dopaminergic Activity

@article{Lindemann2008TraceAR,
  title={Trace Amine-Associated Receptor 1 Modulates Dopaminergic Activity},
  author={Lothar Lindemann and Claas Aiko Meyer and Karine Jeanneau and Amyaouch Bradaia and Laurence Ozmen and Horst Bluethmann and Bernhard Bettler and Joseph G. Wettstein and Edilio Borroni and J. -L. Moreau and Marius Christian Hoener},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2008},
  volume={324},
  pages={948 - 956}
}
The recent identification of the trace amine-associated receptor (TAAR)1 provides an opportunity to dissociate the effects of trace amines on the dopamine transporter from receptor-mediated effects. To separate both effects on a physiological level, a Taar1 knockout mouse line was generated. Taar1 knockout mice display increased sensitivity to amphetamine as revealed by enhanced amphetamine-triggered increases in locomotor activity and augmented striatal release of dopamine compared with wild… 
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42 References

The Trace Amine 1 receptor knockout mouse: an animal model with relevance to schizophrenia

Trace amines have been implicated in a number of neuropsychiatric disorders including depression and schizophrenia. Although long known to modulate neurotransmission indirectly through the release of…

Inhibitory effects of trace amines on rat midbrain dopaminergic neurons

Dopamine transporter‐dependent and ‐independent actions of trace amine β‐phenylethylamine

Comparing the neurochemical and behavioral effects of β‐PEA in wild type, heterozygous and ‘null’ DAT mutant mice and in DAT‐KO mice demonstrates that the DAT is required for the striatal DA‐releasing and hyperlocomotor actions of β-PEA.

Hyperdopaminergia and altered locomotor activity in GABAB1‐deficient mice

mice, which are devoid of functional GABAB receptors, consistently exhibit marked hyperlocomotion when exposed to a novel environment. Telemetry recordings now revealed that, in a familiar…

Trace amines: Identification of a family of mammalian G protein-coupled receptors

Using a degenerate PCR approach, 15 G protein-coupled receptors (GPCR) from human and rodent tissues are identified and it is demonstrated that two of these receptors bind and/or are activated by trace amines.

Enhancement of the NMDA receptor function by reduction of glycine transporter-1 expression

Mammalian central nervous system trace amines. Pharmacologic amphetamines, physiologic neuromodulators

Previous studies showing responses to physiologically relevant concentrations of trace amines are reviewed, along with those showing a reciprocal relationship between trace amine levels and fluctuations in basal monoaminergic tone, and it is hypothesized that the traceAmines function as endogenous neuromodulators of classical monoamine neurotransmitters.

A renaissance in trace amines inspired by a novel GPCR family.

Amphetamine, 3,4-methylenedioxymethamphetamine, lysergic acid diethylamide, and metabolites of the catecholamine neurotransmitters are agonists of a rat trace amine receptor.

The discovery and pharmacological characterization of a rat G protein-coupled receptor that stimulates the production of cAMP when exposed to the trace amines p-tyramine, beta-phenethylamine, tryptamine, and octopamine and the discovery that amphetamines are potent rTAR1 agonists suggests that the effects of these widely used drugs may be mediated in part by this receptor as well as their previously characterized targets, the neurotransmitter transporter proteins.

Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors.