Trace Amine-Associated Receptor 1 Modulates Dopaminergic Activity

  title={Trace Amine-Associated Receptor 1 Modulates Dopaminergic Activity},
  author={Lothar Lindemann and Claas Aiko Meyer and Karine Jeanneau and Amyaouch Bradaia and Laurence Ozmen and Horst Bluethmann and Bernhard Bettler and Joseph G. Wettstein and Edilio Borroni and J. -L. Moreau and Marius Christian Hoener},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  pages={948 - 956}
The recent identification of the trace amine-associated receptor (TAAR)1 provides an opportunity to dissociate the effects of trace amines on the dopamine transporter from receptor-mediated effects. To separate both effects on a physiological level, a Taar1 knockout mouse line was generated. Taar1 knockout mice display increased sensitivity to amphetamine as revealed by enhanced amphetamine-triggered increases in locomotor activity and augmented striatal release of dopamine compared with wild… 

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