• Corpus ID: 25768447

Trabecular bone density in a two year controlled trial of peroral magnesium in osteoporosis.

  title={Trabecular bone density in a two year controlled trial of peroral magnesium in osteoporosis.},
  author={G. Stendig-Lindberg and Roberta L. Tepper and Isaac Leichter},
  journal={Magnesium research},
  volume={6 2},
Since magnesium regulates calcium transport, and magnesium replacement in magnesium-deficient postmenopausal patients resulted in unexpected improvement in documented osteoporosis, we investigated the effect of magnesium treatment on trabecular bone density in postmenopausal osteoporosis. Thirty-one postmenopausal patients (mean age +/- SD = 57.6 +/- 10.6 years), consecutively admitted to the Back Rehabilitation Unit with musculoskeletal pain of non-malignant origin and bone density values of… 

Magnesium Deficiency and Bone Loss After Cardiac Transplantation

A highly significant decline in serum magnesium concentrations, associated with continued urinary magnesium losses, occurs after cardiac transplantation, and patients with low serum magnesium levels had significantly lower rates of bone loss, lower serum PTH concentrations, and lower bone turnover.

Prolonged Magnesium Deficiency Causes Osteoporosis in the Rat

Experimental induced prolonged Mg deficiency causes osteoporosis in rats and the diminution of the trabecular bone volume, in relation to tissue volume (BV/TV and the increase in the degree of trabECular interconnection (TBPf) indicated osteopsorosis.

Delay of Natural Bone Loss by Higher Intakes of Specific Minerals and Vitamins

Increasing the recommended amounts (US RDA 1989), adequate intakes (US DRI 1997), or assumed normal intakes of mentioned food components may lead to a considerable reduction or even prevention of bone loss, especially in late postmenopausal women and the elderly.

A randomized controlled study of effects of dietary magnesium oxide supplementation on bone mineral content in healthy girls.

A positive effect of Mg supplementation on integrated hip BMC was evident in this small cohort of healthy 8- to 14-yr-old Caucasian girls and oral Mg oxide capsules are safe and well tolerated.

Magnesium deficiency: effect on bone mineral density in the mouse appendicular skeleton

This study demonstrates the profound effect of Mg depletion on the trabecular compartment of bone, which, with its greater surface area and turnover, was more responsive to M g depletion than cortical bone in the appendicular skeleton of the mouse.

Daily oral magnesium supplementation suppresses bone turnover in young adult males.

  • H. DimaiS. Porta K. Lau
  • Medicine, Biology
    The Journal of clinical endocrinology and metabolism
  • 1998
Oral Mg supplementation in normal young adults caused reductions in serum levels of iPTH, ionized Mg2+, and biochemical markers of bone turnover, demonstrating for the first time that oral Mg supplements may suppress bone turnover in young adults.

Magnesium Deficiency Induces Bone Loss in the Rat

The data demonstrate that Mg depletion in the rat indicates impaired activation of osteoblasts and an uncoupling of bone formation and bone resorption, and a surprising new observation was an increase in osteoclast (OC) bone Resorption with Mg depleted animals.

Zinc and Magnesium Levels in Osteoporotic Patients from Northern Gaza Strip

Zinc and magnesium levels in the serum are significantly lower in postmenopausal women and men with osteoporosis than control subjects, and it is concluded that low levels of zinc and magnesium may play a role in osteoporeosis.

Comparison of bone tissue trace-element concentrations and mineral density in osteoporotic femoral neck fractures and osteoarthritis

Lower bone levels of Ca, Mg, and Zn are found in patients with osteoporotic fractures compared to subjects with osteoarthritis, and appear to play important roles in bone breakdown/synthesis.

Dietary magnesium supplementation affects bone metabolism and dynamic strength of bone in ovariectomized rats.

The results indicate that magnesium supplementation reduces apparent calcium absorption, but promotes bone formation and prevents bone resorption in OVX rats, and indicates magnesium supplementation increases the dynamic strength of bone.



Does calcium supplementation prevent postmenopausal bone loss? A double-blind, controlled clinical study.

The preliminary data suggest that calcium supplementation in the dosage used is not as effective as estrogen therapy for the prevention of early postmenopausal bone loss.

Treatment of postmenopausal osteoporosis with transdermal estrogen.

Transdermal estradiol treatment is effective in postmenopausal women with established osteoporosis and vertebral fractures and Histomorphometric evaluation of iliac biopsy samples confirmed the effect of estrogen on bone formation rate per bone volume.

Intermittent cyclical etidronate treatment of postmenopausal osteoporosis.

Intermittent cyclical therapy with etidronate for two years significantly increases spinal bone mass and reduces the incidence of new vertebral fractures in women with postmenopausal osteoporosis.

Prevention of early postmenopausal bone loss: controlled 2‐year study in 315 normal females

This study randomized 315 healthy volunteers in their early natural menopause to seven treatment and three placebo groups, with the aim of preventing postmenopausal bone loss.

A total dietary program emphasizing magnesium instead of calcium. Effect on the mineral density of calcaneous bone in postmenopausal women on hormonal therapy.

The use of calcium supplementation for the management of primary postmenopausal osteoporosis (PPMO) has increased significantly in the past few years. A review of the published data does not support

Dietary intake and bone mineral density.

The results suggest that bone mass is influenced by dietary factors other than calcium, and iron, zinc and magnesium intake were positively correlated with forearm BMC in premenopausal women.

Preliminary report of decreased serum magnesium in postmenopausal osteoporosis.

If these results are confirmed in a long-term study, serum Mg might be added to a batch of tests used to discriminate a subset of patients with an increased risk of developing postmenopausal osteoporosis.

Dietary intake of calcium and postmenopausal bone loss.

The results of this study suggest that the bone density of women in the early menopause is not influenced by current dietary intake of calcium.

Evidence for efficacy of drugs affecting bone metabolism in preventing hip fracture.

Oestrogen, calcium, and calcitonins significantly decrease the risk of hip fracture, and short term intervention late in the natural course of osteoporosis may have significant effects on the incidence of hip fractures.

Effects of magnesium on skeletal metabolism.

  • S. Wallach
  • Medicine, Biology
    Magnesium and trace elements
  • 1990
Bone Mg is uniformly increased in renal insufficiency and may play a role in renal osteodystrophy since improvement has been noted in the osteomalacic component by normalizing the serum Mg.