• Corpus ID: 25768447

Trabecular bone density in a two year controlled trial of peroral magnesium in osteoporosis.

@article{StendigLindberg1993TrabecularBD,
  title={Trabecular bone density in a two year controlled trial of peroral magnesium in osteoporosis.},
  author={G. Stendig-Lindberg and Roberta L. Tepper and Isaac Leichter},
  journal={Magnesium research},
  year={1993},
  volume={6 2},
  pages={
          155-63
        }
}
Since magnesium regulates calcium transport, and magnesium replacement in magnesium-deficient postmenopausal patients resulted in unexpected improvement in documented osteoporosis, we investigated the effect of magnesium treatment on trabecular bone density in postmenopausal osteoporosis. Thirty-one postmenopausal patients (mean age +/- SD = 57.6 +/- 10.6 years), consecutively admitted to the Back Rehabilitation Unit with musculoskeletal pain of non-malignant origin and bone density values of… 

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References

SHOWING 1-10 OF 41 REFERENCES

Does calcium supplementation prevent postmenopausal bone loss? A double-blind, controlled clinical study.

The preliminary data suggest that calcium supplementation in the dosage used is not as effective as estrogen therapy for the prevention of early postmenopausal bone loss.

Treatment of postmenopausal osteoporosis with transdermal estrogen.

Transdermal estradiol treatment is effective in postmenopausal women with established osteoporosis and vertebral fractures and Histomorphometric evaluation of iliac biopsy samples confirmed the effect of estrogen on bone formation rate per bone volume.

Intermittent cyclical etidronate treatment of postmenopausal osteoporosis.

Intermittent cyclical therapy with etidronate for two years significantly increases spinal bone mass and reduces the incidence of new vertebral fractures in women with postmenopausal osteoporosis.

Prevention of early postmenopausal bone loss: controlled 2‐year study in 315 normal females

This study randomized 315 healthy volunteers in their early natural menopause to seven treatment and three placebo groups, with the aim of preventing postmenopausal bone loss.

A total dietary program emphasizing magnesium instead of calcium. Effect on the mineral density of calcaneous bone in postmenopausal women on hormonal therapy.

The use of calcium supplementation for the management of primary postmenopausal osteoporosis (PPMO) has increased significantly in the past few years. A review of the published data does not support

Dietary intake and bone mineral density.

The results suggest that bone mass is influenced by dietary factors other than calcium, and iron, zinc and magnesium intake were positively correlated with forearm BMC in premenopausal women.

Preliminary report of decreased serum magnesium in postmenopausal osteoporosis.

If these results are confirmed in a long-term study, serum Mg might be added to a batch of tests used to discriminate a subset of patients with an increased risk of developing postmenopausal osteoporosis.

Dietary intake of calcium and postmenopausal bone loss.

The results of this study suggest that the bone density of women in the early menopause is not influenced by current dietary intake of calcium.

Evidence for efficacy of drugs affecting bone metabolism in preventing hip fracture.

Oestrogen, calcium, and calcitonins significantly decrease the risk of hip fracture, and short term intervention late in the natural course of osteoporosis may have significant effects on the incidence of hip fractures.

Effects of magnesium on skeletal metabolism.

  • S. Wallach
  • Medicine, Biology
    Magnesium and trace elements
  • 1990
Bone Mg is uniformly increased in renal insufficiency and may play a role in renal osteodystrophy since improvement has been noted in the osteomalacic component by normalizing the serum Mg.