Tr1 cells and the counter-regulation of immunity: natural mechanisms and therapeutic applications.


T regulatory Type 1 (Tr1) cells are adaptive T regulatory cells characterized by the ability to secrete high levels of IL-10 and minimal amounts of IL-4 and IL-17. Recently, CD49b and LAG-3 have been identified as Tr1-cell-specific biomarkers in mice and humans. Tr1 cells suppress T-cell- and antigen-presenting cell- (APC) responses primarily via the… (More)
DOI: 10.1007/978-3-662-43492-5_3


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