Tr1 Cells, but Not Foxp3+ Regulatory T Cells, Suppress NLRP3 Inflammasome Activation via an IL-10-Dependent Mechanism.

@article{Yao2015Tr1CB,
  title={Tr1 Cells, but Not Foxp3+ Regulatory T Cells, Suppress NLRP3 Inflammasome Activation via an IL-10-Dependent Mechanism.},
  author={Yu Yao and Jens Vent-Schmidt and Matthew D. McGeough and May Q. Wong and Hal M. Hoffman and Theodore S Steiner and Megan K Levings},
  journal={Journal of immunology},
  year={2015},
  volume={195 2},
  pages={
          488-97
        }
}
The two best-characterized types of CD4(+) regulatory T cells (Tregs) are Foxp3(+) Tregs and Foxp3(-) type 1 regulatory (Tr1) cells. The ability of Foxp3(+) Tregs and Tr1 cells to suppress adaptive immune responses is well known, but how these cells regulate innate immunity is less defined. We discovered that CD44(hi)Foxp3(-) T cells from unmanipulated mice are enriched in Tr1 cell precursors, enabling differentiation of cells that express IL-10, as well as Tr1-associated cell surface markers… CONTINUE READING
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