Tpt1 Activates Transcription of oct4 and nanog in Transplanted Somatic Nuclei

  title={Tpt1 Activates Transcription of oct4 and nanog in Transplanted Somatic Nuclei},
  author={Magdalena J Koziol and Nigel J Garrett and John Bertrand Gurdon},
  booktitle={Current Biology},
Nuclear transfer to eggs or oocytes provides a potential route for cell-replacement therapies because oocytes directly reprogram transplanted mammalian somatic-cell nuclei such that they have an embryo-like pattern of gene expression. This includes a large increase in the mRNA level of the stem-cell marker gene oct4. We have developed a novel procedure to identify new proteins that greatly increase the level of oct4 mRNA upon nuclear transfer. We have isolated Xenopus oocyte proteins that bind… CONTINUE READING


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