Toxoplasma gondii infection reduces predator aversion in rats through epigenetic modulation in the host medial amygdala

@article{HariDass2014ToxoplasmaGI,
  title={Toxoplasma gondii infection reduces predator aversion in rats through epigenetic modulation in the host medial amygdala},
  author={Shantala Arundathi Hari Dass and Ajai Vyas},
  journal={Molecular Ecology},
  year={2014},
  volume={23}
}
Male rats (Rattus novergicus) infected with protozoan Toxoplasma gondii relinquish their innate aversion to the cat odours. This behavioural change is postulated to increase transmission of the parasite to its definitive felid hosts. Here, we show that the Toxoplasma gondii infection institutes an epigenetic change in the DNA methylation of the arginine vasopressin promoter in the medial amygdala of male rats. Infected animals exhibit hypomethylation of arginine vasopressin promoter, leading to… Expand
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An epigenetic basis is proposed for an epigenetic change in arginine vasopressin gene in medial amygdala of male rats that resulted in reduction of fear to cat odors in uninfected animals, thus suggesting sufficiency. Expand
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  • Medicine, Biology
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