Toxoplasma gondii induces FAK-Src-STAT3 signaling during infection of host cells that prevents parasite targeting by autophagy

@inproceedings{Portillo2017ToxoplasmaGI,
  title={Toxoplasma gondii induces FAK-Src-STAT3 signaling during infection of host cells that prevents parasite targeting by autophagy},
  author={Jose-Andres C Portillo and Luis Muniz-Feliciano and Yalitza Lopez Corcino and So Jung Lee and Jennifer Van Grol and Sarah J Parsons and William P Schiemman and Carlos S Subauste},
  booktitle={PLoS pathogens},
  year={2017}
}
Targeting of Toxoplasma gondii by autophagy is an effective mechanism by which host cells kill the protozoan. Thus, the parasite must avoid autophagic targeting to survive. Here we show that the mammalian cytoplasmic molecule Focal Adhesion Kinase (FAK) becomes activated during invasion of host cells. Activated FAK appears to accompany the formation of the moving junction (as assessed by expression the parasite protein RON4). FAK activation was inhibited by approaches that impaired β1 and β3… CONTINUE READING
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