Toxoplasma gondii dense granule protein 3 (GRA3) is a type I transmembrane protein that possesses a cytoplasmic dilysine (KKXX) endoplasmic reticulum (ER) retrieval motif.

@article{Henriquez2005ToxoplasmaGD,
  title={Toxoplasma gondii dense granule protein 3 (GRA3) is a type I transmembrane protein that possesses a cytoplasmic dilysine (KKXX) endoplasmic reticulum (ER) retrieval motif.},
  author={Fiona L. Henriquez and Mohammad B Nickdel and Rima McLeod and Russell E. Lyons and Katie B Lyons and Jean François Dubremetz and Michael E. Grigg and Benjamin Samuel and Craig W Roberts},
  journal={Parasitology},
  year={2005},
  volume={131 Pt 2},
  pages={169-79}
}
Studies using antibodies to immunolocalize the Toxoplasma gondii dense granule protein GRA3, have shown that this protein associates strongly with the parasitophorous vacuole membrane (PVM). However, as there was no predicted membrane-spanning domain this highlighted an unanswered paradox. We demonstrate that the previously published sequence for GRA3 is actually an artificial chimera of 2 proteins. One protein, of molecular weight 65 kDa, shares the C-terminus with published GRA3 and possesses… CONTINUE READING
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