Toxoplasma gondii cyclic GMP-dependent kinase: chemotherapeutic targeting of an essential parasite protein kinase.

@article{Donald2002ToxoplasmaGC,
  title={Toxoplasma gondii cyclic GMP-dependent kinase: chemotherapeutic targeting of an essential parasite protein kinase.},
  author={Robert G K Donald and John J Allocco and Suresh B. Singh and Bakela Nare and Scott P. Salowe and Judyann Wiltsie and Paul A. Liberator},
  journal={Eukaryotic cell},
  year={2002},
  volume={1 3},
  pages={317-28}
}
The trisubstituted pyrrole 4-[2-(4-fluorophenyl)-5-(1-methylpiperidine-4-yl)-1H-pyrrol-3-yl]pyridine (compound 1) has in vivo activity against the apicomplexan parasites Toxoplasma gondii and Eimeria tenella in animal models. The presumptive molecular target of this compound in E. tenella is cyclic GMP-dependent protein kinase (PKG). Native PKG purified from T. gondii has kinetic and pharmacologic properties similar to those of the E. tenella homologue, and both have been functionally expressed… CONTINUE READING