Toxoplasma gondii and other risk factors for schizophrenia: an update.

@article{Torrey2012ToxoplasmaGA,
  title={Toxoplasma gondii and other risk factors for schizophrenia: an update.},
  author={E Fuller Torrey and John J. Bartko and Robert H. Yolken},
  journal={Schizophrenia bulletin},
  year={2012},
  volume={38 3},
  pages={
          642-7
        }
}
The failure to find genes of major effect in schizophrenia has refocused attention on nongenetic, including infectious factors. In a previous study, antibodies to Toxoplasma gondii were found to be elevated in 23 studies of schizophrenia (OR 2.73; 95% CI 2.10-3.60). The current study replicates this finding with 15 additional studies (OR 2.71; 95% CI 1.93-3.80) and compares this with other identified schizophrenia risk factors. The highest risk factors are having an affected mother (relative… 

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References

SHOWING 1-10 OF 52 REFERENCES
Antibodies to Toxoplasma gondii in patients with schizophrenia: a meta-analysis.
TLDR
The results suggest that individuals with schizophrenia have an increased prevalence of antibodies to T. gondii, and this association is consistent with other epidemiological studies as well as with animal studies.
Relation Between Toxoplasma Gondii Infections and Schizophrenia
TLDR
An epidemiological association between Toxoplasma gondii infections and schizophrenia was not observed and the proportion of seropositive subjects was significantly lower in the first-episode patients than in the next episodes.
The role of latent toxoplasmosis in the aetiopathogenesis of schizophrenia--the risk factor or an indication of a contact with cat?
TLDR
The data suggest that the toxoplasmosis has no direct effect on the risk of schizophrenia in Turkey but is just an indication of previous contacts with a cat.
A possible relationship between Toxoplasma gondii and schizophrenia: A seroprevalence study
TLDR
The findings supported previous studies indicate that T.gondii may play a role in etiopathogenesis in some cases of schizophrenia and supported the view that schizophrenia is a pervasive neuropsychiatric disease of uncertain etiology.
The schizophrenia and Toxoplasma gondii connection: Infectious, immune or both?
TLDR
This study found that IgG T gondii antibodies were significantly higher in schizophrenia patients compared with controls, and supports the theory that toxoplasmic agents may have a role in the aetiology of schizophrenia.
A controlled prospective study of toxoplasma gondii infection in individuals with schizophrenia: beyond seroprevalence.
TLDR
The results support increased host responses to TG infection in the patients, as well as increased titers in first-episode patients with schizophrenia; this may relate to the shifted T-helper 1/2 status described in these patients.
Serological survey of Toxoplasma gondii in schizophrenia patients referred to Psychiatric Hospital, Sari City, Iran.
TLDR
It seems that designing a cohort study will determine the causative relationship between Toxoplasma infection and schizophrenia, as prevalence rate of T. gondii antibodies in patients with schizophrenia was high.
Toxoplasma gondii infection in first-episode and inpatient individuals with schizophrenia.
Possible role of toxoplasmosis in patients with first-episode schizophrenia.
TLDR
Toxoplasmosis might be associated with first-episode schizophrenia, and more studies are needed to prove the association between T. gondii infection and patients suffering from schizophrenia.
...
...