Toxoplasma gondii acyl-lipid metabolism: de novo synthesis from apicoplast-generated fatty acids versus scavenging of host cell precursors.

@article{Bisanz2006ToxoplasmaGA,
  title={Toxoplasma gondii acyl-lipid metabolism: de novo synthesis from apicoplast-generated fatty acids versus scavenging of host cell precursors.},
  author={Cordelia Bisanz and Olivier Bastien and Delphine Grando and Juliette Jouhet and Eric Mar{\'e}chal and Marie-France Cesbron-Delauw},
  journal={The Biochemical journal},
  year={2006},
  volume={394 Pt 1},
  pages={197-205}
}
Toxoplasma gondii is an obligate intracellular parasite that contains a relic plastid, called the apicoplast, deriving from a secondary endosymbiosis with an ancestral alga. Metabolic labelling experiments using [14C]acetate led to a substantial production of numerous glycero- and sphingo-lipid classes in extracellular tachyzoites. Syntheses of all these lipids were affected by the herbicide haloxyfop, demonstrating that their de novo syntheses necessarily required a functional apicoplast fatty… CONTINUE READING