Toxoplasma gondii Antibody Titers and History of Suicide Attempts in Patients With Recurrent Mood Disorders

  title={Toxoplasma gondii Antibody Titers and History of Suicide Attempts in Patients With Recurrent Mood Disorders},
  author={Timothy A Arling and Robert H. Yolken and Manana Lapidus and Patricia W. Langenberg and Faith B Dickerson and Sarah A. Zimmerman and Theodora G Balis and Johanna A. Cabassa and Debra A. Scrandis and Leonardo H Tonelli and Teodor Τ Postolache,},
  journal={The Journal of Nervous and Mental Disease},
Toxoplasma gondii (T.gondii) is an obligate intracellular protozoan parasite infecting one-third of the world population, residing relatively silently in the brain of the immunocompetent host. We hypothesized that T.gondii seropositivity and serointensity are associated with having a history of attempting suicide and, in those attempting suicide, a greater number of attempts. T.gondii seropositivity and antibody titers were compared between (a) patients with recurrent mood disorders with… 

The Association between Suicide Attempts and Toxoplasma gondii Infection

  • Jeongjae BakSe-Hoon Shim Y. Lee
  • Psychology, Medicine
    Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology
  • 2018
A significant association between T. gondii infection and psychiatric problems in suicidality is suggested and suicide attempters showed higher seroprevalence of T. Gondii than healthy controls.

Toxoplasma gondii infection: relationship with aggression in psychiatric subjects.

These data are consistent with previous studies suggesting a relationship between T. gondii and self-directed aggression and further add to the biological complexity of impulsive aggression both from a categorical and a dimensional perspective.

Toxoplasmosis Titers and past Suicide Attempts Among Older Adolescents Initiating SSRI Treatment

  • W. CoryellR. Yolken C. Calarge
  • Psychology, Medicine
    Archives of suicide research : official journal of the International Academy for Suicide Research
  • 2016
Toxoplasmosis titers may quantify a proneness to suicidal behavior in younger individuals being treated with antidepressants in younger adolescents who had recently begun treatment with an SSRI.

Association of Suicide Attempt With Seroprevalence of Toxoplasma gondii in Adolescents.

Adolescents attempting suicide were found to have worse relationships with their parents; their CDI scores were higher, and their RSES scores were lower than their healthy peers.

Toxoplasma gondii Infection and Suicide Attempts: A Case-Control Study in Psychiatric Outpatients

The results suggest that although seroprevalence of Toxoplasma infection is not associated with suicide attempts, a high anti-Toxoplasm antibody level is, therefore warranting further research.

Toxoplasma gondii and anxiety disorders in a community-based sample

Toxoplasma gondii Seropositivity and Suicide Rates in Women

It is suggested that a positive relationship between rates of infection with T. gondii and suicide is apparent in women of postmenopausal age, and mechanisms mediating this relationship are explored.

Latent Toxoplasmosis is Associated with Depression and Suicidal Behavior

Latent toxoplasmosis may represent be a risk factor for depression and suicidal behavior and screening for, and treatment of, underlying T. gondii infection may help improve depression and curb the increasing suicide rates.



Selected infectious agents and risk of schizophrenia among U.S. military personnel.

A hypothesis-generating case control study of T. gondii IgG antibody and schizophrenia among individuals discharged from the U.S. military with a diagnosis of schizophrenia and serum specimens available from both before and after diagnosis found significant associations.

Antibodies to Toxoplasma gondii in patients with schizophrenia: a meta-analysis.

The results suggest that individuals with schizophrenia have an increased prevalence of antibodies to T. gondii, and this association is consistent with other epidemiological studies as well as with animal studies.

Antibodies to infectious agents in individuals with recent onset schizophrenia

It is found that untreated individuals with recent onset schizophrenia had significantly increased levels of serum and CSF IgG antibody to cytomegalovirus and Toxoplasma gondii as compared to controls and that treatment status had a major effect on the levels of antibodies in this population.

Decrease of psychomotor performance in subjects with latent ‘asymptomatic’ toxoplasmosis

This is the first study confirming the existence of such parasite-induced changes in human behaviour that could be considered in evolutionary history of the human species as adaptive from the point of view of parasite transmission.

Increased risk of traffic accidents in subjects with latent toxoplasmosis: a retrospective case-control study

The results suggest that 'asymptomatic' acquired toxoplasmosis might in fact represent a serious and highly underestimated public health problem, as well as an economic problem.

Are some cases of psychosis caused by microbial agents? A review of the evidence

The protozoan Toxoplasma gondii and cytomegalovirus are discussed as examples of infectious agents that have been linked to schizophrenia and in which genes and infectious agents interact.

The immunobiology of the innate response to Toxoplasma gondii.

Irritability Rather Than Depression During Interferon Treatment Is Linked to Increased Tryptophan Catabolism

Aggressive impulse dysregulation is highly prevalent in patients receiving interferon treatment, associated with decreased plasma tryptophan levels which may lead to attenuated peripheral and central serotonergic neurotransmission.