Toxoplasma gondii ADP-ribosylation factor 1 mediates enhanced release of constitutively secreted dense granule proteins.

@article{Liendo2001ToxoplasmaGA,
  title={Toxoplasma gondii ADP-ribosylation factor 1 mediates enhanced release of constitutively secreted dense granule proteins.},
  author={A Liendo and Timothy T Stedman and Hu{\^a}n M. Ng{\^o} and Shalini Chaturvedi and Heinrich C Hoppe and Keith A. Joiner},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 21},
  pages={18272-81}
}
Toxoplasma gondii dense granules are morphologically similar to dense matrix granules in specialized secretory cells, yet are secreted in a constitutive, calcium-independent fashion. We previously demonstrated that secretion of dense granule proteins in permeabilized parasites was augmented by the non-hydrolyzable GTP analogue guanosine 5'-3-O-(thio)triphosphate (GTPgammaS) (Chaturvedi, S., Qi, H., Coleman, D. L., Hanson, P., Rodriguez, A., and Joiner, K. A. (1998) J. Biol. Chem. 274, 2424-2431… CONTINUE READING

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