Toxoplasma gondii: prototype immunization of lambs against formation of muscle and brain cysts.

  title={Toxoplasma gondii: prototype immunization of lambs against formation of muscle and brain cysts.},
  author={Jes{\'u}s Falc{\'o}n and Alvaro Freyre},
  journal={Veterinary parasitology},
  volume={166 1-2},
Nine lambs were immunized with 10(6) oocysts of the relatively avirulent ME-49 strain of Toxoplasma gondii, and were challenged 45 days later with 4 x 10(6) oocysts of the M3 strain of this parasite. Less than 5 tissue cysts of the M3 strain formed per 8 g of muscle - if any - judging from a bioassay in mice in which all mice survived. In contrast, mortality occurred in mice fed muscle specimens from 4 lambs that had not been immunized with ME-49 prior to challenge with the M3 strain. This… CONTINUE READING

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