Toxoplasma gondii: DNA vaccination with bradyzoite antigens induces protective immunity in mice against oral infection with parasite cysts.

@article{Nielsen2006ToxoplasmaGD,
  title={Toxoplasma gondii: DNA vaccination with bradyzoite antigens induces protective immunity in mice against oral infection with parasite cysts.},
  author={Henrik Vedel Nielsen and Manlio Di Cristina and Elisa Beghetto and Andrea Spadoni and Eskild Petersen and Nicola Gargano},
  journal={Experimental parasitology},
  year={2006},
  volume={112 4},
  pages={274-9}
}
Infection of the host by Toxoplasma gondii leads to an acute systemic dissemination of tachyzoites, followed by a chronic phase, in which bradyzoites, enclosed in cysts, persist in the brain, the heart, and other tissues. Among putative vaccine candidates, the bradyzoite antigens BAG1 and MAG1 look promising since they are preferentially expressed during the chronic stage of the parasite. This work focused on studying the immunogenicity of bradyzoite antigens in a mouse model of chronic… CONTINUE READING

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