Toxoplasma depends on lysosomal consumption of autophagosomes for persistent infection

  title={Toxoplasma depends on lysosomal consumption of autophagosomes for persistent infection},
  author={Manlio Di Cristina and Zhicheng Dou and Matteo Lunghi and Geetha Kannan and M S Huynh and Olivia L. McGovern and Tracey L Schultz and Aric J. Schultz and Alyssa J. Miller and Beth M. Hayes and Wouter A. van der Linden and Carla Emiliani and Matthew S Bogyo and S{\'e}bastien Besteiro and Isabelle Coppens and Vern B Carruthers},
  booktitle={Nature Microbiology},
Globally, nearly 2 billion people are infected with the intracellular protozoan Toxoplasma gondii1. This persistent infection can cause severe disease in immunocompromised people and is epidemiologically linked to major mental illnesses2 and cognitive impairment3. There are currently no options for curing this infection. The lack of effective therapeutics is due partly to a poor understanding of the essential pathways that maintain long-term infection. Although it is known that Toxoplasma… CONTINUE READING
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