Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologue

@article{Saeij2007ToxoplasmaCH,
  title={Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologue},
  author={Jeroen P. J. Saeij and S P Coller and Jon P Boyle and Maria E Jerome and Michael W White and John C Boothroyd},
  journal={Nature},
  year={2007},
  volume={445},
  pages={324-327}
}
Toxoplasma gondii, an obligate intracellular parasite of the phylum Apicomplexa, can cause severe disease in humans with an immature or suppressed immune system. The outcome of Toxoplasma infection is highly dependent on the strain type, as are many of its in vitro growth properties. Here we use genetic crosses between type II and III lines to show that strain-specific differences in the modulation of host cell transcription are mediated by a putative protein kinase, ROP16. Upon invasion by the… CONTINUE READING

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