Toxoplasma Effector TgIST Targets Host IDO1 to Antagonize the IFN-γ-Induced Anti-parasitic Response in Human Cells

@inproceedings{Bando2018ToxoplasmaET,
  title={Toxoplasma Effector TgIST Targets Host IDO1 to Antagonize the IFN-γ-Induced Anti-parasitic Response in Human Cells},
  author={Hironori Bando and Naoya Sakaguchi and Youngae Lee and Ariel Pradipta and Ji Su Ma and Shun Tanaka and De-Hua Lai and Jianfa Liu Liu and Zhao-rong Lun and Yoshifumi Nishikawa and Miwa Sasai and Masahiro Yamamoto},
  booktitle={Front. Immunol.},
  year={2018}
}
Toxoplasma gondii is an important human and animal pathogen that causes life-threatening toxoplasmosis. Interferon-γ (IFN-γ) is critical for anti-T. gondii cell-autonomous immunity in both humans and mice. To proliferate efficiently within the hosts, virulent strains of T. gondii can suppress IFN-γ-dependent immunity. During parasite infection, it is well-characterized that various virulence effectors are secreted to transcriptionally or post-translationally target IFN-γ-inducible GTPases… CONTINUE READING

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