Toxopain-1 is critical for infection in a novel chicken embryo model of congenital toxoplasmosis.

@article{Que2004Toxopain1IC,
  title={Toxopain-1 is critical for infection in a novel chicken embryo model of congenital toxoplasmosis.},
  author={Xuchu Que and Annette Wunderlich and Keith A. Joiner and Sharon L Reed},
  journal={Infection and immunity},
  year={2004},
  volume={72 5},
  pages={
          2915-21
        }
}
We tested the hypothesis that cathepsins and specifically toxopain-1, a cathepsin B, play a critical role in the pathogenesis of toxoplasmosis. We found that inhibiting the expression of toxopain-1-specific mRNA and protein by >60% significantly decreased the capacity of the parasites to multiply and invade in vitro. To relate these in vitro results to the role of toxopain-1 in pathogenesis in vivo, we developed a novel chicken embryo model of congenital toxoplasmosis. Inhibiting either… CONTINUE READING

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