Toxins affecting cell signalling and alteration of cytoskeletal structure.

@article{Toivola1999ToxinsAC,
  title={Toxins affecting cell signalling and alteration of cytoskeletal structure.},
  author={D M Toivola and John E. Eriksson},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={1999},
  volume={13 4-5},
  pages={
          521-30
        }
}
Many natural toxins act by modifying key functions of the phosphorylation-based signalling machinery. Microcystins comprise a good example of highly specific, signalling-targeted toxicants. These liver-specific cyanobacterial peptide toxins act as potent inhibitors of serine/threonine (ser/thr) protein phosphatases, in particular type-1 (PP1) and type-2A (PP2A). PP1 and PP2A regulate the phosphorylation of a large number of key elements in various signalling processes. Furthermore, they are… CONTINUE READING

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