Toxin-resistant sodium channels: parallel adaptive evolution across a complete gene family.

@article{Jost2008ToxinresistantSC,
  title={Toxin-resistant sodium channels: parallel adaptive evolution across a complete gene family.},
  author={Manda Clair Jost and David M. Hillis and Ying Lu and John W. Kyle and Harry A. Fozzard and Harold H Zakon},
  journal={Molecular biology and evolution},
  year={2008},
  volume={25 6},
  pages={1016-24}
}
Approximately 75% of vertebrate proteins belong to protein families encoded by multiple evolutionarily related genes, a pattern that emerged as a result of gene and genome duplications over the course of vertebrate evolution. In families of genes with similar or related functions, adaptation to a strong selective agent should involve multiple adaptive… CONTINUE READING