Toxin-deficient mutants of Bacillus anthracis are lethal in a murine model for pulmonary anthrax.

@article{Heninger2006ToxindeficientMO,
  title={Toxin-deficient mutants of Bacillus anthracis are lethal in a murine model for pulmonary anthrax.},
  author={Sara Heninger and Melissa Drysdale and Julie A. Lovchik and Julie A. Hutt and Mary Lipscomb and Theresa M Koehler and C. Rick Lyons},
  journal={Infection and immunity},
  year={2006},
  volume={74 11},
  pages={6067-74}
}
Bacillus anthracis, the etiologic agent of anthrax, produces at least three primary virulence factors: lethal toxin, edema toxin, and a capsule. The capsule is absolutely required for dissemination and lethality in a murine model of inhalation anthrax, yet the roles for the toxins during infection are ill-defined. We show in a murine model that when spores of specific toxin-null mutants are introduced into the lung, dissemination and lethality are comparable to those of the parent strain… CONTINUE READING

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