Toxin-antitoxin systems influence biofilm and persister cell formation and the general stress response.

@article{Wang2011ToxinantitoxinSI,
  title={Toxin-antitoxin systems influence biofilm and persister cell formation and the general stress response.},
  author={Xiaoxue Wang and Thomas K. Wood},
  journal={Applied and environmental microbiology},
  year={2011},
  volume={77 16},
  pages={5577-83}
}
In many genomes, toxin-antitoxin (TA) systems have been identified; however, their role in cell physiology has been unclear. Here we examine the evidence that TA systems are involved in biofilm formation and persister cell formation and that these systems may be important regulators of the switch from the planktonic to the biofilm lifestyle as a stress response by their control of secondary messenger 3',5'-cyclic diguanylic acid. Specifically, upon stress, the sequence-specific mRNA… CONTINUE READING

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Antitoxin MqsA mediates the bacterial general stress response

  • X Wang
  • Nat. Chem. Biol
  • 2011
Highly Influential
9 Excerpts

Three dimensional structure of the MqsR:MqsA complex: a novel toxin:antitoxin pair comprised of a toxin homologous to RelE and an antitoxin with unique properties

  • Brown, L B.
  • PLoS Pathog. 5:e1000706
  • 2009
Highly Influential
5 Excerpts

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