Toxin and kinetic profile of rat brain type III sodium channels expressed in Xenopus oocytes.

  title={Toxin and kinetic profile of rat brain type III sodium channels expressed in Xenopus oocytes.},
  author={Rolf H. Joho and Jay R. Moorman and Antonius M. J. VanDongen and Glenn E. Kirsch and H A Silberberg and Gabriele Schuster and Arthur M. Brown},
  journal={Brain research. Molecular brain research},
  volume={7 2},
Sodium (Na+) channels are members of a multigene family and are responsible for generation and propagation of the action potential in excitable cells. We have assembled, in a transcription-competent vector, a full-length cDNA clone encoding the rat brain type III Na+ channel. Xenopus oocytes microinjected with in vitro synthesized mRNA expressed functional rat brain Na+ channels from such 'cloned' RNA transcripts. We found that type III Na+ currents in whole cell microelectrode voltage clamp… CONTINUE READING

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