Toxicometabolomics approach to urinary biomarkers for mercuric chloride (HgCl₂)-induced nephrotoxicity using proton nuclear magnetic resonance (¹H NMR) in rats.

@article{Kim2010ToxicometabolomicsAT,
  title={Toxicometabolomics approach to urinary biomarkers for mercuric chloride (HgCl₂)-induced nephrotoxicity using proton nuclear magnetic resonance (¹H NMR) in rats.},
  author={Kyu-Bong Kim and So Young Um and Myeon Woo Chung and Seung Chul Jung and Ji Seon Oh and Seon Hwa Kim and Han Sung Na and Byung Mu Lee and Ki Hwan Choi},
  journal={Toxicology and applied pharmacology},
  year={2010},
  volume={249 2},
  pages={114-26}
}
The primary objective of this study was to determine and characterize surrogate biomarkers that can predict nephrotoxicity induced by mercuric chloride (HgCl₂) using urinary proton nuclear magnetic resonance (¹H NMR) spectral data. A procedure for (1)H NMR urinalysis using pattern recognition was proposed to evaluate nephrotoxicity induced by HgCl₂ in Sprague-Dawley rats. HgCl₂ at 0.1 or 0.75 mg/kg was administered intraperitoneally (i.p.), and urine was collected every 24 h for 6 days. Animals… CONTINUE READING