Toxicology of trans-1,2-dichloroethylene in the mouse.

  title={Toxicology of trans-1,2-dichloroethylene in the mouse.},
  author={David W. Barnes and Virginia M. Sanders and Kimber L. White and Geogre M. Shopp and Albert E. Munson},
  journal={Drug and chemical toxicology},
  volume={8 5},
Trans-1,2-dichloroethylene (DCE) was administered to male and female CD-1 mice in order to evaluate its effects on standard toxicological parameters. Following an acute LD50 determination (2122 mg/kg in males and 2391 mg/kg in females) and a 14-day range-finding study, a 90-day drinking water study was performed using levels of DCE calculated to deliver approximately 1/100, 1/10, and 1/5 the LD50. Various toxicological assessments were made, including body and organ weights, hematology, serum… CONTINUE READING