Toxicology and risk assessment of coumarin: focus on human data.

  title={Toxicology and risk assessment of coumarin: focus on human data.},
  author={Klaus Abraham and Friederike Woehrlin and Oliver Lindtner and Gerhard Heinemeyer and A. Lampen},
  journal={Molecular nutrition & food research},
  volume={54 2},
Coumarin is a secondary phytochemical with hepatotoxic and carcinogenic properties. For the carcinogenic effect, a genotoxic mechanism was considered possible, but was discounted by the European Food Safety Authority in 2004 based on new evidence. This allowed the derivation of a tolerable daily intake (TDI) for the first time, and a value of 0.1 mg/kg body weight was arrived at based on animal hepatotoxicity data. However, clinical data on hepatotoxicity from patients treated with coumarin as… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 12 times over the past 90 days. VIEW TWEETS

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 34 extracted citations

Similar Papers

Loading similar papers…