Toxicology and risk assessment of coumarin: focus on human data.

@article{Abraham2010ToxicologyAR,
  title={Toxicology and risk assessment of coumarin: focus on human data.},
  author={Klaus Abraham and Friederike Woehrlin and Oliver Lindtner and Gerhard Heinemeyer and A. Lampen},
  journal={Molecular nutrition & food research},
  year={2010},
  volume={54 2},
  pages={228-39}
}
Coumarin is a secondary phytochemical with hepatotoxic and carcinogenic properties. For the carcinogenic effect, a genotoxic mechanism was considered possible, but was discounted by the European Food Safety Authority in 2004 based on new evidence. This allowed the derivation of a tolerable daily intake (TDI) for the first time, and a value of 0.1 mg/kg body weight was arrived at based on animal hepatotoxicity data. However, clinical data on hepatotoxicity from patients treated with coumarin as… CONTINUE READING
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