• Corpus ID: 44543897

Toxicology and Carcinogenesis Studies of 8-Methoxypsoralen (CAS No. 298-81-7) in F344/N Rats (Gavage Studies).

  title={Toxicology and Carcinogenesis Studies of 8-Methoxypsoralen (CAS No. 298-81-7) in F344/N Rats (Gavage Studies).},
  author={June K. Dunnick},
  journal={National Toxicology Program technical report series},
  • J. Dunnick
  • Published 1989
  • Medicine, Biology
  • National Toxicology Program technical report series
Oral administration of 8-methoxypsoralen followed by exposure to longwave ultraviolet light (primarily ultraviolet A, 320-400 nm) is used in the treatment of vitiligo and psoriasis. 8-Methoxypsoralen also occurs naturally in a variety of vegetables. Toxicology and carcinogenesis studies of 8-methoxypsoralen without ultraviolet A were conducted by administering USP-grade 8-methoxypsoralen (99% pure) in corn oil by gavage to groups of F344/N rats once or for 16 days, 13 weeks, or 2 years. In… 

Development and characterization of an in vivo skin photomicronucleus assay in rats.

In vivo rat skin photomicronucleus test may be a promising tool for detection of photoclastogenicity and help bridge the gap in the existing photosafety testing paradigm.

Levels of Genotoxic and Carcinogenic Compounds in Plant Food Supplements and Associated Risk Assessment

The use of PFS containing the genotoxic carcinogens estragole, methyleugenol, safrole or β-asarone might raise a potential concern for human health and would be of high priority for risk management.


  • Chemistry
  • 2012
Chem. Abstr. Serv. Reg. No.: 298-81-7 Chem. Abstr. Name: 9-Methoxy-7Hfuro[3,2-g][1]benzopyran-7-one IUPAC Systematic Name: 9-Methoxyfuro[3,2-g]chromen-7-one Synonyms: 5-Benzofuranacrylic acid,

Methoxsalen with ultraviolet A therapy.

  • Medicine
    Report on carcinogens : carcinogen profiles
  • 2011
Supporting the association between skin cancer and PUVA exposure are several case reports of skin cancer (basal-cell and squamous-cell carcinoma and malignant melanoma) in patients treated with PUVA for psoriasis or mycosis fungoides.

Pharmacophore modeling and in silico toxicity assessment of potential anticancer agents from African medicinal plants

In this study, pharmacophore models have been generated and validated for use in virtual screening protocols for eight known anticancer drug targets, indicating that several of the models generated could be useful for the identification of potential anticancer agents from natural product databases.