• Corpus ID: 44543897

Toxicology and Carcinogenesis Studies of 8-Methoxypsoralen (CAS No. 298-81-7) in F344/N Rats (Gavage Studies).

@article{Dunnick1989ToxicologyAC,
  title={Toxicology and Carcinogenesis Studies of 8-Methoxypsoralen (CAS No. 298-81-7) in F344/N Rats (Gavage Studies).},
  author={June K. Dunnick},
  journal={National Toxicology Program technical report series},
  year={1989},
  volume={359},
  pages={
          1-130
        }
}
  • J. Dunnick
  • Published 1989
  • Medicine, Biology
  • National Toxicology Program technical report series
Oral administration of 8-methoxypsoralen followed by exposure to longwave ultraviolet light (primarily ultraviolet A, 320-400 nm) is used in the treatment of vitiligo and psoriasis. 8-Methoxypsoralen also occurs naturally in a variety of vegetables. Toxicology and carcinogenesis studies of 8-methoxypsoralen without ultraviolet A were conducted by administering USP-grade 8-methoxypsoralen (99% pure) in corn oil by gavage to groups of F344/N rats once or for 16 days, 13 weeks, or 2 years. In… 

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Chem. Abstr. Serv. Reg. No.: 298-81-7 Chem. Abstr. Name: 9-Methoxy-7Hfuro[3,2-g][1]benzopyran-7-one IUPAC Systematic Name: 9-Methoxyfuro[3,2-g]chromen-7-one Synonyms: 5-Benzofuranacrylic acid,

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Supporting the association between skin cancer and PUVA exposure are several case reports of skin cancer (basal-cell and squamous-cell carcinoma and malignant melanoma) in patients treated with PUVA for psoriasis or mycosis fungoides.

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