Disrupted Murine Gut-to-Human Liver Signaling Alters Bile Acid Homeostasis in Humanized Mouse Liver Models.
C R E D IT : V . A LT O U N IA N /S C IE N C E , A D A P T E D F R O M G . P E LT Z , T R E N D S I N P H A R M A C O L O G IC A L S C IE N C E S , 3 4 ( M A Y 2 0 1 3 ) After fi ve patients died in a small clinical trial of an experimental hepatitis B drug in 1993, high-level committees scrambled to work out what went wrong. In the end, they blamed not the researchers but the lab animals. Earlier studies, including several in animals, simply failed to show that the drug was toxic. Now, researchers say they have developed an animal model that would have detected the drug’s toxicity: an engineered mouse with a humanlike liver. They say it could serve as a versatile testbed for liver toxicity, a worrisome side effect of many drugs.